Anthrax is a topic covered in the Johns Hopkins ABX Guide.

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PATHOGENS

  • Bacillus anthracis (Category A bio-terrorism agent)
  • Spore is primary infectious form.
  • Virulence factors:
    • Antiphagocytic capsule
    • Exotoxins: why anti-toxin therapies have been developed given the prominence of these toxins in causing illness.
      • Edema toxin (ET)
      • Lethal toxin (LT)
      • Protective antigen (PA) combines ET and LT and facilitates entry into cells and assists in downregulating immune responses.

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Last updated: March 5, 2019