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Ampicillin + Sulbactam

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D., Alice Jenh Hsu, Pharm.D.

Ampicillin + Sulbactam is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

Gynecologic infections: by beta-lactamase producing strains of E. coli, and Bacteroides spp. (including B. fragilis).
Intra-abdominal infections: by beta-lactamase producing strains of E. coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
Skin and soft tissue infections: by S. aureus (MSSA), E. coli, Klebsiella spp. (including K. pneumoniae), P. mirabilis, B. fragilis, Enterobacter spp., and A. calcoaceticus.

NON-FDA APPROVED USES

Epiglottitis (H. influenzae)
Head and neck infections
Hepatic abscess (consider in mild disease)
Diabetic foot infection (w/ mild superficial ulcer)
Aspiration pneumonia
Bite wounds (Eikenella corrodens, Pasteurella multocida)
Culture negative endocarditis or endocarditis caused by HACEK organisms
Surgical prophylaxis
Infections caused by Acinetobacter spp.
NOTE: it is not recommended empirically for intra-abdominal infections due to high rates of resistance to E. coli.

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Last updated: September 3, 2016

Citation

Avdic, Edina, et al. "Ampicillin + Sulbactam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam.

Avdic E, Pham PA, Jenh Hsu A. Ampicillin + Sulbactam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam. Accessed February 22, 2019.

Avdic, E., Pham, P. A., & Jenh Hsu, A. (2016). Ampicillin + Sulbactam. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam

Avdic E, Pham PA, Jenh Hsu A. Ampicillin + Sulbactam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 February 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam

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TY - ELEC T1 - Ampicillin + Sulbactam ID - 540024 A1 - Avdic,Edina,Pharm.D. AU - Jenh Hsu,Alice,Pharm.D. AU - Pham,Paul,Pharm.D. Y1 - 2016/09/03/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -