Amphotericin B cholesteryl sulfate complex (ABCD)
- Manufacturing currently suspended in U.S.
- Invasive aspergillosis in patients who are refractory to or intolerant of amphotericin B deoxycholate therapy
Amphotericin B cholesteryl sulfate complex (ABCD)
(Ben Venue Laboratories)
*Prices represent cost per unit specified, are representative of "Average Wholesale Price" (AWP).
^Dosage is indicated in mg unless otherwise noted.
USUAL ADULT DOSING
USUAL PEDIATRIC DOSING
- Children: 4 mg/kg/dose IV q24h (max dose 7.5 mg/kg/dose)
PEDIATRIC RENAL DOSING
No renal dosage adjustment in patients with renal insufficiency
DOSING FOR GLOMERULAR FILTRATION OF 50-80
DOSING FOR GLOMERULAR FILTRATION OF 10-50
Usual dose. Monitor closely for worsening renal function.
DOSING FOR GLOMERULAR FILTRATION OF <10 ML/MIN
DOSING IN HEMODIALYSIS
Not removed in dialysis, no supplement needed post HD. Usual dose.
DOSING IN PERITONEAL DIALYSIS
DOSING IN HEMOFILTRATION
ADVERSE DRUG REACTIONS
- Infusion reactions: fever (27%), chills (53%), phlebitis, pain at infusion site.
- Infusion related reactions were the highest in amphotec treated patients compared to all amphotericin products, including regular amphotericin.
- Infusion reactions lower with routine premedication (hydrocortisone, NSAID, ASA, meperidine).
- Creatinine elevation (>2x baseline) observed in up to 25% on ABCD.
- Electrolyte wasting: hypokalemia, hypomagnesemia, and hypocalcemia
- Nausea, vomiting, diarrhea, abdominal pain
- Metallic taste
- Headache and insomnia
- Transaminase elevations
- Increased in bilirubin (>1.5x baseline)
- Rash and pruritis
- Digoxin: potential increase in digitalis toxicity secondary to amphotericin-induced potassium depletion. Monitor potassium closely with co-administration.
- Diuretics: may result in additive hypokalemia. Monitor potassium closely with co-administration.
- Nephrotoxic agents (aminoglycosides, cidofovir, foscarnet, pentamidine): may result in additive nephrotoxicity. Avoid co-administration or use with close monitoring.
- Pentamidine: potential for additive hypocalcemia and/or nephrotoxicity. Avoid co-administration or use with close monitoring.
- Skeletal muscle relaxants: may enhance curariform effect of skeletal muscle relaxants (e.g., tubocurarine) due to hypokalemia. Monitor potassium closely with co-administration.
Aspergillus spp (A. fumigatus, A. flavus), Candida spp (C. albicans, C. krusei, C. parapsilosis, C. tropicalis), Cryptococcus neoformans, and Blastomyces dermatitidis. Active against most fungi with the notable exceptions of Candida lusitaniae, Trichosporon beigelii, Aspergillus terreus (some isolates), Pseudallescheria boydii, Malassezia furfur and Fusarium spp.
Amphotericin binds to ergosterol in fungal cell membrane, resulting in the disruption of the cell membrane. As a result the cell membrane is no longer able to function as a selective barrier and leakage of intracellular contents occurs. The lipid formulations are designed to reduce binding of amphotericin to mammalian cell membranes, therefore reducing toxicities.
Not absorbed from the GI tract.
Metabolism and Excretion
Cmax, Cmin, and AUC
2-9 mcg/ml after 4mg/kg IV dose administration.
Attains lower serum concentration but has greater volume of distribution (vd = 4 L/kg) compared to conventional amphotericin. Increased uptake by the liver and spleen and decreased kidney concentration. Poor fat distribution (animal data)
DOSING FOR DECREASED HEPATIC FUNCTION
No data. Usual dose likely in mild/moderate hepatic insufficiency
B- There is limited data on the use of Amphotericin B cholesteryl sulfate complex in pregnancy; therefore the use should be limited to patients where the benefit outweighs the risk.
BREAST FEEDING COMPATIBILITY
No data available.
- Current shortage due to voluntary suspension of all manufacturing and distribution by Alkopharma.
- Parenteral lipid amphotericin that was the least expensive of all lipid formulations, but also associated with the highest infusion-related side effects compared to standard amphotericin B and other lipid amphotericin formulations.
- Ambisome and Abelcet are generally preferred over Amphotec for most indications.
- Infectious Diseases Society of America, et al. "Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 46, no. 3, 2008, pp. 327-60. [PMID:18177225]
Comment: The IDSA guidelines recommend Ambisome (3â??5 mg/kg/day IV) or Abelcet (5 mg/ kg/day IV) as alternatives to voriconazole for the treatment of invasive aspergillosis.
- PRoACT Investigators, et al. "Pre-medication Practices and Incidence of Infusion-related Reactions in Patients Receiving AMPHOTEC: Data From the Patient Registry of Amphotericin B Cholesteryl Sulfate Complex for Injection Clinical Tolerability (PRoACT) Registry." The Journal of Antimicrobial Chemotherapy, vol. 62, no. 6, 2008, pp. 1392-400. [PMID:18812423]
Comment: Previous data suggested higher rates of infusion related reactions with ABCD as compared to conventional amphotericin as well as the other lipid formulations. This was largely due to lack of the use of premedications, which have now become routine in clinical practice. This data suggests that the incidence of infusion related reactions is lower than previously thought when corticosteroids are used prior to ABCD administration; acetaminophen and antihistamine use, though, had no effect.
- Bowden, Raleigh, et al. "A Double-blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion Versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 35, no. 4, 2002, pp. 359-66. [PMID:12145716]
Comment: This is a multicenter randomized, double-blind trial of Amphotec (ABCD)6 mg/kg/day vs. Amphotericin B 1.0-1.5 mg/kg/day for treatment of invasive aspergillosis in 174 patients. The results of this trial showed Amphotec and Amphotericin B are comparable in therapeutic efficacy for invasive aspergillosis. The study was under powered to detect a potential difference, nevertheless,overall responses was poor in both groups (17% in the ABCD group vs.23% in the ampho B group).The advantage of ABCD is the reduced rate of nephrotoxicity, but this advantage is offset by a comparable rate of complications requiring discontinuation due to infusion-related adverse reactions.
- Bowden, R A., et al. "Randomized, Double-blind Clinical Trial of Amphotericin B Colloidal Dispersion Vs. Amphotericin B in the Empirical Treatment of Fever and Neutropenia." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 27, no. 2, 1998, pp. 296-302. [PMID:9709879]
Comment: This trial demonstrated that Amphotec was equivalent to standard amphotericin B for the empiric treatment of febrile neutropenia. The frequency of renal dysfunction was decreased with Amphotec, but more infusion related-reaction was seen. The rate of infusion-related reactions seen in this study is consistent with that seen with historical controls where Amphotec demonstrated the highest incidence of infusion related reaction compared to all other forms of amphotericin including standard Amphotericin B.
- Abboud, M, et al. "Use of Amphotericin B Colloidal Dispersion in Children." Journal of Pediatric Hematology/oncology, vol. 22, no. 3, 2000 May-Jun, pp. 242-6. [PMID:10864055]
Comment: Amphotec (ABCD) dosed at 4 mg/kg/day (up to 7.5mg/kg/day) was well tolerated in children.
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