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Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Amoxicillin is a topic covered in the Johns Hopkins ABX Guide.

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Treatment of infections due to susceptible (β-lactamase-negative) strains causing following syndromes:

  • Infections of the ear, nose, and throat – due to Streptococcus spp. (α- and β-hemolytic strains), S. pneumoniae, Staphylococcus spp., or H. influenzae
  • Infections of the genitourinary tract – due to E. coli, P. mirabilis, or E. faecalis. Note: empiric use is not recommended by IDSA due to higher rates of resistance to E. coli and poor efficacy[3].
  • Infections of the skin and skin structure – due to Streptococcus spp. (α- and β-hemolytic strains), Staphylococcus spp., or E. coli
  • Infections of the lower respiratory tract – due to Streptococcus spp. (α- and β-hemolytic strains), S. pneumoniae, Staphylococcus spp., or H. influenzae
  • Gonorrhea, acute uncomplicated (ano-genital and urethral infections) – due to N. gonorrhoeae (males and females). Note: amoxicillin is not recommended by CDC for the treatment of gonorrhea due to high rates of resistance.
  • H. pylori eradication to reduce the risk of duodenal ulcer recurrence in combination with other agents.

Amoxicillin ER tablet (Mmoxtag™) is indicated for the treatment of tonsillitis and/or pharyngitis secondary to Streptococcus pyogenes in adults and pediatric patients ≥12 y/o


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Last updated: March 7, 2019


Avdic, Edina, and Paul A Pham. "Amoxicillin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin.
Avdic E, Pham PA. Amoxicillin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin. Accessed July 22, 2019.
Avdic, E., & Pham, P. A. (2019). Amoxicillin. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin
Avdic E, Pham PA. Amoxicillin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 July 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin.
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TY - ELEC T1 - Amoxicillin ID - 540017 A1 - Avdic,Edina,Pharm.D. AU - Pham,Paul,Pharm.D. Y1 - 2019/03/07/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -