Johns Hopkins ABX Guide
Amikacin
INDICATIONS
FDA
FDA
- Amikacin sulfate is indicated in the short-term treatment of serious infections due to susceptible organisms.
- [Except uncomplicated UTI, aminoglycosides are generally used in combination for serious infections including treatment of Pseudomonas aeruginosa.]
- Bacterial septicemia (including neonatal sepsis)
- Respiratory tract infections
- Bone and joint infections
- Central nervous system infections
- Skin and soft tissue infections (including burns and postoperative infections)
- Intra-abdominal infections
- Complicated and recurrent urinary tract infections.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third-/fourth-generation cephalosporin)
- Adjunctive prophylaxis with aerosolized amikacin has demonstrated some benefits in preventing ventilator-associated pneumonia in ICU patients.
- Adjunctive therapy with aerosolized amikacin has not been proven to provide additional benefits in comparison to standard-of-care intravenous therapy alone.
- Tuberculosis
- Non-tubercular mycobacterial (NTM) infections, MAI
- Nocardia
- Aerosolized amikacin has been used for the management of cystic fibrosis exacerbations.
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Last updated: October 19, 2024
Citation
Y. Vivian Tsai, Pharm.D., and Kathryn Dzintars. "Amikacin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2024. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540015/all/Amikacin.
Y. Vivian Tsai, Pharm.D., Dzintars K. Amikacin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540015/all/Amikacin. Accessed November 4, 2025.
Y. Vivian Tsai, Pharm.D., & Dzintars, K. (2024). Amikacin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540015/all/Amikacin
Y. Vivian Tsai, Pharm.D., Dzintars K. Amikacin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. [cited 2025 November 04]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540015/all/Amikacin.
* Article titles in AMA citation format should be in sentence-case
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PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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