Trypanosoma brucei gambiense/rhodesiense is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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  • Protozoan hemoflagellate, agent of human African sleeping sickness.
  • Zoonotic infection of cattle, transmitted by painful bite of TseTse fly ( Fig 1, not preventable with DEET) in rural African locales.
    • Other modes of transmission possible: vertical (mother → child), sexual contact (rare), laboratory-related
  • Trypanosoma brucei complex of which two subspecies exist:
    • T. b. gambiense causes West African sleeping sickness
    • T. b. rhodesiense causes East African sleeping sickness

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Last updated: October 4, 2015