Johns Hopkins ABX Guide
Acanthamoeba
Acanthamoeba is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Free-living amoeba, ubiquitous, and can be isolated worldwide from soil, air, and fresh- and saltwater.
- See also N. fowleri. for details on this organism.
- Eukaryotic, shares homologies with mammalian cells.[10]
- Life cycle consists of 2 stages: mobile trophozoite, the infective stage, is 14-40 um in diameter, and the dormant cyst is double-walled and wrinkled.
- The cyst is resistant to chlorine and antibiotics. Encystation occurs under stress.
- The transition from cyst to trophozoite occurs optimally in vitro at 30°C or 86°F.[6]
- Described as “Trojan horses” because acanthamoebae can harbor intracellular bacteria.[12]
- Treatment of bacterial endosymbionts may attenuate inflammation associated with acanthamoebae infection.[7]
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MICROBIOLOGY
- Free-living amoeba, ubiquitous, and can be isolated worldwide from soil, air, and fresh- and saltwater.
- See also N. fowleri. for details on this organism.
- Eukaryotic, shares homologies with mammalian cells.[10]
- Life cycle consists of 2 stages: mobile trophozoite, the infective stage, is 14-40 um in diameter, and the dormant cyst is double-walled and wrinkled.
- The cyst is resistant to chlorine and antibiotics. Encystation occurs under stress.
- The transition from cyst to trophozoite occurs optimally in vitro at 30°C or 86°F.[6]
- Described as “Trojan horses” because acanthamoebae can harbor intracellular bacteria.[12]
- Treatment of bacterial endosymbionts may attenuate inflammation associated with acanthamoebae infection.[7]
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Last updated: December 9, 2019
Citation
Spacek, Lisa A. "Acanthamoeba." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540002/all/Acanthamoeba.
Spacek LA. Acanthamoeba. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540002/all/Acanthamoeba. Accessed May 24, 2022.
Spacek, L. A. (2019). Acanthamoeba. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540002/all/Acanthamoeba
Spacek LA. Acanthamoeba [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2022 May 24]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540002/all/Acanthamoeba.
* Article titles in AMA citation format should be in sentence-case
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T1 - Acanthamoeba
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A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2019/12/09/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540002/all/Acanthamoeba
PB - The Johns Hopkins University
DB - Johns Hopkins Guide
DP - Unbound Medicine
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