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- Ketamine hydrochloride is a general anesthetic used at sub-anesthetic doses for off-label treatment of depressive symptoms. It is notable as both an unusually fast-acting antidepressant (within 4 hrs) and a psychomimetic agent (meaning that it in higher doses it can mimic psychosis). Due to ketamine’s dissociative and psychomimetic effects, its administration is done under clinical supervision. An intranasal preparation of the S enantiomer of ketamine (esketamine, brand name SPRAVATO) is FDA approved for TRD.
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Last updated: April 2, 2019
Wang, Mike, and Paul Nestadt. "Ketamine." Johns Hopkins Psychiatry Guide, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/all/Ketamine.
Wang M, Nestadt P. Ketamine. Johns Hopkins Psychiatry Guide. 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/all/Ketamine. Accessed November 15, 2019.
Wang, M., & Nestadt, P. (2019). Ketamine. In Johns Hopkins Psychiatry Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/all/Ketamine
Wang M, Nestadt P. Ketamine [Internet]. In: Johns Hopkins Psychiatry Guide. ; 2019. [cited 2019 November 15]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/all/Ketamine.
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T1 - Ketamine
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DP - Unbound Medicine