Johns Hopkins Psychiatry Guide
Ketamine
Ketamine is a topic covered in the Johns Hopkins Psychiatry Guide.
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DESCRIPTION
- Ketamine hydrochloride is a general anesthetic used at sub-anesthetic doses for off-label treatment of depressive symptoms. It is notable as both an unusually fast-acting antidepressant (within 4 hrs) and a psychomimetic agent (meaning that it in higher doses it can mimic psychosis). Due to ketamine’s dissociative and psychomimetic effects, its administration is done under clinical supervision. An intranasal preparation of the S enantiomer of ketamine (esketamine, brand name SPRAVATO) is FDA approved for TRD.[1][2]
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DESCRIPTION
- Ketamine hydrochloride is a general anesthetic used at sub-anesthetic doses for off-label treatment of depressive symptoms. It is notable as both an unusually fast-acting antidepressant (within 4 hrs) and a psychomimetic agent (meaning that it in higher doses it can mimic psychosis). Due to ketamine’s dissociative and psychomimetic effects, its administration is done under clinical supervision. An intranasal preparation of the S enantiomer of ketamine (esketamine, brand name SPRAVATO) is FDA approved for TRD.[1][2]
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Last updated: April 2, 2019
Citation
Wang, Mike, and Paul Nestadt. "Ketamine." Johns Hopkins Psychiatry Guide, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/9/Ketamine.
Wang M, Nestadt P. Ketamine. Johns Hopkins Psychiatry Guide. 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/9/Ketamine. Accessed October 20, 2020.
Wang, M., & Nestadt, P. (2019). Ketamine. In Johns Hopkins Psychiatry Guide Retrieved October 20, 2020, from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/9/Ketamine
Wang M, Nestadt P. Ketamine [Internet]. In: Johns Hopkins Psychiatry Guide. ; 2019. [cited 2020 October 20]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/9/Ketamine.
* Article titles in AMA citation format should be in sentence-case
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T1 - Ketamine
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AU - Nestadt,Paul,M.D.
Y1 - 2019/04/02/
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UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787373/9/Ketamine
DB - Johns Hopkins Guide
DP - Unbound Medicine
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