The FDA issued an Emergency Use Authorization (EUA) for the emergency use of molnupiravir for the treatment of mild-to-moderate COVID-19 in adults at high risk for progressing to severe COVID-19 disease, including hospitalization and death.
- Risk for progression includes age > 60, diabetes, obesity (BMI ≥ 30), chronic kidney disease, serious heart conditions, chronic obstructive pulmonary disease, or active cancer.
- Authorized for treatment within the first 5d of symptomatic COVID-19 illness.
- In February 2023, the FDA updated the EUA by removing the need for a positive COVID-19 viral test to prescribe the medication
Molnupiravir is NOT authorized for:
- Patients < 18 years of age
- Patients requiring hospitalization for the management of COVID-19 disease (benefit has not been observed in patients beginning treatment after hospitalization)
- Use longer than 5 consecutive days
- Pre-exposure or post-exposure prophylaxis for the prevention of COVID-19 disease
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Last updated: February 6, 2023
Dzintars, Kathryn . "Molnupiravir." Johns Hopkins HIV Guide, 2023. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545312/all/Molnupiravir.
Dzintars K. Molnupiravir. Johns Hopkins HIV Guide. 2023. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545312/all/Molnupiravir. Accessed June 10, 2023.
Dzintars, K. (2023). Molnupiravir. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545312/all/Molnupiravir
Dzintars K. Molnupiravir [Internet]. In: Johns Hopkins HIV Guide. ; 2023. [cited 2023 June 10]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545312/all/Molnupiravir.
* Article titles in AMA citation format should be in sentence-case
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