The FDA fully approved (2023) drug after initial Emergency Use Authorization (EUA) for the emergency use of Paxlovid (nirmatrelvir/ritonavir) for the treatment of mild-to-moderate COVID-19 disease in adults and children ≥ 12 years of age who are at high risk for progressing to severe COVID-19 illness, including hospitalization and death.
- Risk factors for severe disease include diabetes, overweight (BMI >25), chronic lung disease, chronic kidney disease, current smoker, immunosuppressive disease or immunosuppressive treatment, cardiovascular disease, hypertension, sickle cell disease, neurodevelopmental disorders, active cancer, and patients >60 years of age.
- The FDA removed an earlier requirement for a positive SARS-CoV-2 test from the EUA in February 2023.
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Last updated: November 12, 2023
Auwaerter, Paul G, and Kathryn Dzintars. "Nirmatrelvir/Ritonavir." Johns Hopkins HIV Guide, 2023. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545311/all/Nirmatrelvir_Ritonavir.
Auwaerter PG, Dzintars K. Nirmatrelvir/Ritonavir. Johns Hopkins HIV Guide. 2023. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545311/all/Nirmatrelvir_Ritonavir. Accessed December 7, 2023.
Auwaerter, P. G., & Dzintars, K. (2023). Nirmatrelvir/Ritonavir. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545311/all/Nirmatrelvir_Ritonavir
Auwaerter PG, Dzintars K. Nirmatrelvir/Ritonavir [Internet]. In: Johns Hopkins HIV Guide. ; 2023. [cited 2023 December 07]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545311/all/Nirmatrelvir_Ritonavir.
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