Remdesivir

Edina Avdic, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS
Remdesivir is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

  • Remdesivir is approved for the treatment of coronavirus disease 2019 (COVID-19) requiring hospitalization in adult and pediatric patients (12 years of age and older, and who weigh at least 40kg)
  • Remdesivir is not FDA approved in children < 12 years of age, but remains authorized for use in the U.S. by the FDA under an Emergency Use Authorization (EUA) for treatment of suspected or laboratory-confirmed SARS-Co-2 infection (COVID-19) in children hospitalized with severe diseases.
  • Severe disease is defined as:
    • Patients with SpO2 ≤ 94% on room air, OR
    • Requiring supplemental oxygen, OR
    • Requiring mechanical ventilation, OR
    • Requiring extracorporeal membrane oxygenation (ECMO)

NON-FDA APPROVED USES

  • Nonhospitalized patients who are at high risk for disease progression may be given a 3-day course of remdesivir (200 mg IV on day 1, then 100 mg IV on days 2 and 3)

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INDICATIONS

FDA

  • Remdesivir is approved for the treatment of coronavirus disease 2019 (COVID-19) requiring hospitalization in adult and pediatric patients (12 years of age and older, and who weigh at least 40kg)
  • Remdesivir is not FDA approved in children < 12 years of age, but remains authorized for use in the U.S. by the FDA under an Emergency Use Authorization (EUA) for treatment of suspected or laboratory-confirmed SARS-Co-2 infection (COVID-19) in children hospitalized with severe diseases.
  • Severe disease is defined as:
    • Patients with SpO2 ≤ 94% on room air, OR
    • Requiring supplemental oxygen, OR
    • Requiring mechanical ventilation, OR
    • Requiring extracorporeal membrane oxygenation (ECMO)

NON-FDA APPROVED USES

  • Nonhospitalized patients who are at high risk for disease progression may be given a 3-day course of remdesivir (200 mg IV on day 1, then 100 mg IV on days 2 and 3)

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Last updated: January 14, 2022