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Paul A. Pham, Pharm.D., David L. Thomas, M.D., M.P.H.
Simeprevir is a topic covered in the Johns Hopkins HIV Guide.

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  • In combination with Peg-IFN and ribavirin, simeprevir is FDA indicated for the treatment of HCV genotype 1 in patients with compensated liver disease (including cirrhosis).
  • Since lower efficacy has been observed in some studies in patients infected with HCV genotype 1a with NS3 Q80K* polymorphism, screening for this polymorphism at baseline is recommended if simeprevir use is planned.
  • If NS3 Q80K polymorphism is detected, use of an alternative directly acting HCV regimen should be considered.

*In clinical trials, prevalence of Q80K polymorphism observed in 30% patients infected with HCV genotype1a and only 0.5% in patients infected with HCV genotype 1b.


Simeprevir plus sofosbuvir +/- ribavirin is a recommended first line regimen for the treatment of HCV genotype 1a and 1b. NS3 Q80K polymorphism for genotype 1a did not significantly impact sustained virologic response to this regimen.

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Last updated: May 7, 2014


Pham, Paul A, and David L Thomas. "Simeprevir." Johns Hopkins HIV Guide, 2014. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545244/all/Simeprevir.
Pham PA, Thomas DL. Simeprevir. Johns Hopkins HIV Guide. 2014. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545244/all/Simeprevir. Accessed July 21, 2019.
Pham, P. A., & Thomas, D. L. (2014). Simeprevir. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545244/all/Simeprevir
Pham PA, Thomas DL. Simeprevir [Internet]. In: Johns Hopkins HIV Guide. ; 2014. [cited 2019 July 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545244/all/Simeprevir.
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TY - ELEC T1 - Simeprevir ID - 545244 A1 - Pham,Paul,Pharm.D. AU - Thomas,David,M.D., M.P.H. Y1 - 2014/05/07/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545244/all/Simeprevir DB - Johns Hopkins Guide DP - Unbound Medicine ER -