Janessa Smith, Pharm.D., BCPS, Paul A. Pham, Pharm.D.



  • CNS and ocular toxoplasmosis (in combination with pyrimethamine)
  • FDA indicated, but not generally recommended:
    • Chancroid
    • Trachoma
    • Inclusion conjunctivitis
    • Prophylaxis of meningococcal meningitis when sulfonamide-sensitive group A strains known to prevail
    • Meningococcal meningitis
    • Acute otitis media due to H. influenzae(in combination with PCN)
    • Prophylaxis against recurrences of rheumatic fever (alternative to penicillin)
    • H. influenzae meningitis (in combination with streptomycin)
    • UTI (including pyelonephritis)
    • Malaria due to chloroquine-resistant P. falciparum malaria (in combination with quinine and pyrimethamine)
    • Nocardiosis

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Last updated: October 2, 2017