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Resistance testing: phenotype

Resistance testing: phenotype is a topic covered in the Johns Hopkins HIV Guide.

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DEFINITION

  • In phenotypic resistance assays, RT, PR, integrase and envelope gene sequences derived from patient plasma HIV RNA are used to measure HIV replication at different concentrations of ARVs.
  • Phenotypic co-receptor tropism assays detect CCR5, CXCR4, or dual/mixed (D/M)-tropic virus. Viral tropism is the ability of HIV to bind to different co-receptors on target cells to achieve viral entry, used to assess activity of CCR5 antagonist (maraviroc).[6]

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Last updated: January 3, 2016

Citation

Spacek, Lisa A. "Resistance Testing: Phenotype." Johns Hopkins HIV Guide, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545178/all/Resistance_testing:_phenotype.
Spacek LA. Resistance testing: phenotype. Johns Hopkins HIV Guide. 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545178/all/Resistance_testing:_phenotype. Accessed July 19, 2019.
Spacek, L. A. (2016). Resistance testing: phenotype. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545178/all/Resistance_testing:_phenotype
Spacek LA. Resistance Testing: Phenotype [Internet]. In: Johns Hopkins HIV Guide. ; 2016. [cited 2019 July 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545178/all/Resistance_testing:_phenotype.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Resistance testing: phenotype ID - 545178 A1 - Spacek,Lisa,M.D., Ph.D. Y1 - 2016/01/03/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545178/all/Resistance_testing:_phenotype DB - Johns Hopkins Guide DP - Unbound Medicine ER -