- HSV-1 and HSV-2 are double-stranded, enveloped DNA viruses of the α-herpesviruses. Herpes from Greek "to creep".
- Distributed worldwide. High rates of seroprevalence to HSV-1 by adulthood, seroprevalence of HSV-2 related to sexual activity.
- 70% of those living with HIV are HSV-2 seropositive and 95% are HSV-1 or HSV-2 seropositive. HSV-2 increases risk of HIV acquisition and transmission.
- A chronic, life-long infection with acute episodes; establishes latency in sensory ganglia at site of initial mucocutaneous infection.
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Last updated: September 3, 2021
Spacek, Lisa A. "Herpes Simplex." Johns Hopkins HIV Guide, 2021. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex.
Spacek LA. Herpes simplex. Johns Hopkins HIV Guide. 2021. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex. Accessed December 6, 2023.
Spacek, L. A. (2021). Herpes simplex. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex
Spacek LA. Herpes Simplex [Internet]. In: Johns Hopkins HIV Guide. ; 2021. [cited 2023 December 06]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex.
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