Tags

Type your tag names separated by a space and hit enter

Cytomegalovirus is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

MICROBIOLOGY

  • Member of Betaherpesviridae, double-stranded DNA virus with envelope; viral DNA polymerase is target for antivirals. Histology reveals large basophilic intranuclear ’owl’s eye’ and intracytoplasmic inclusion bodies.
  • Transmission via saliva, blood, semen, cervical secretions, breast milk, urine, or feces.
  • Latency established after infection. 60-100% seroprevalence. As high as 90-100% seroprevalence in HIV+ individuals. High-frequency of CMV-specific CD4+ and CD8+ memory T cells circulating in blood.[11]
    • Reactivation of latent infection increases w/ advancing immune suppression and is responsible for most HIV-related disease.
  • Persistent immune activation and chronic inflammation due to HIV may be modified by CMV infection.[10]
  • Recent studies detail contribution of CMV to immune activation[13] and non-AIDS-defining events, such as malignancy, cardiovascular and cerebrovascular events, nonvascular neurologic diseases, and ESRD, in HIV+ adults.[12]

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: April 2, 2019

Citation

Spacek, Lisa A. "Cytomegalovirus." Johns Hopkins HIV Guide, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus.
Spacek LA. Cytomegalovirus. Johns Hopkins HIV Guide. 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus. Accessed July 18, 2019.
Spacek, L. A. (2019). Cytomegalovirus. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus
Spacek LA. Cytomegalovirus [Internet]. In: Johns Hopkins HIV Guide. ; 2019. [cited 2019 July 18]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Cytomegalovirus ID - 545048 A1 - Spacek,Lisa,M.D., Ph.D. Y1 - 2019/04/02/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus DB - Johns Hopkins Guide DP - Unbound Medicine ER -