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- Uncomplicated UTI (ciprofloxacin XR and ciprofloxacin), complicated UTI (ciprofloxacin).
- Post-exposure prophylaxis for inhalation anthrax. CDC recommends as first line agent + 1-2 additional agent(s) with in vitro activity (for inhalation anthrax, see "biodefense-anthrax" module).
- Complicated intra-abdominal infections (in combination with metronidazole)
- Infectious diarrhea
- Endocervical and urethral infections caused N. gonorrhoeae (high resistance rates reported in Hawaii and California).
- Empiric therapy for neutropenic fever (in combination with piperacillin); typhoid fever
- Nosocomial pneumonia
- Acute sinusitis
- Skin and soft tissue infections; bone and joint infections 11) bacterial conjunctivitis (ophthalmic ointment) 12) bacterial conjuctivitis and corneal ulcers (ophthalmic solution) 13) Acute otitis externa (otic suspension)