Johns Hopkins Diabetes GuideManagementType 1 Diabetes

Pancreatic and Islet Transplantation

Aniket R. Sidhaye, M.D., Gregory Clark, M.D.
Pancreatic and Islet Transplantation is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

  • Pancreas transplant (PTx) refers to allo-transplantation (human to human) of the whole pancreas, including islets of Langerhans, acinar tissue, pancreatic ducts and blood vessels. Pancreas transplant alone (PTA) refers to pancreas transplantation without a transplanted kidney.
  • Simultaneous pancreas and kidney transplant (SPK) involves transplanting both a pancreas and a kidney simultaneously.
  • Pancreas after kidney (PAK) refers to PTx in a recipient who has already received a kidney transplant.
  • Islet autotransplantation is separation of islets from a person’s own pancreas and retransplantation of those islets into the same person.
  • Islet allotransplantation is separation of islets of Langerhans (1-2% of pancreas mass) from a donor pancreas, transplanted by infusion via the portal vein into a recipient.

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Last updated: June 19, 2013