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Autoantibodies in Type 1 Diabetes

Thomas Donner, M.D., Shivam Champaneri, M.D., Christopher Saudek, M.D.
Autoantibodies in Type 1 Diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

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  • 4 autoantibodies are markers of beta cell autoimmunity in type 1 diabetes: Islet Cell Antibodies (ICA, against cytoplasmic proteins in the beta cell), antibodies to Glutamic Acid Decarboxylase (GAD-65), Insulin Autoantibodies (IAA), and IA-2A, to protein tyrosine phosphatase [2] .
  • Autoantibodies against GAD 65 are found in 80% of type 1 diabetics at clinical presentation [3] .
  • Presence of ICA and IA-2A at diagnosis for type 1 diabetes range from 69-90% and 54-75%, respectively [11] .
  • IAA prevalence correlates inversely with age at onset of diabetes; it is usually the first marker in young children at risk for diabetes [17] and found in approximately 70% of young children at time of diagnosis [1] .

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Last updated: October 6, 2015


Donner, Thomas, et al. "Autoantibodies in Type 1 Diabetes." Johns Hopkins Diabetes Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes.
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes. Johns Hopkins Diabetes Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes. Accessed July 18, 2019.
Donner, T., Champaneri, S., & Saudek, C. (2015). Autoantibodies in Type 1 Diabetes. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2015. [cited 2019 July 18]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Autoantibodies in Type 1 Diabetes ID - 547013 A1 - Donner,Thomas,M.D. AU - Champaneri,Shivam,M.D. AU - Saudek,Christopher,M.D. Y1 - 2015/10/06/ BT - Johns Hopkins Diabetes Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes DB - Johns Hopkins Guide DP - Unbound Medicine ER -