Autoantibodies in Type 1 Diabetes
is a topic covered in the Johns Hopkins Diabetes Guide
To view the entire topic, please sign in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
4 autoantibodies are markers of beta cell autoimmunity in type 1 diabetes: Islet Cell Antibodies (ICA, against cytoplasmic proteins in the beta cell), antibodies to Glutamic Acid Decarboxylase (GAD-65), Insulin Autoantibodies (IAA), and IA-2A, to protein tyrosine
Autoantibodies against GAD 65 are found in 80% of type 1 diabetics at clinical presentation
Presence of ICA and IA-2A at diagnosis for type 1 diabetes range from 69-90% and 54-75%, respectively
IAA prevalence correlates inversely with age at onset of diabetes; it is usually the first marker in young children at risk for diabetes
and found in approximately 70% of young children at time of diagnosis
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
Last updated: October 6, 2015
Donner, Thomas, et al. "Autoantibodies in Type 1 Diabetes." Johns Hopkins Diabetes Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/2/Autoantibodies_in_Type_1_Diabetes.
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes. Johns Hopkins Diabetes Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/2/Autoantibodies_in_Type_1_Diabetes. Accessed July 21, 2019.
Donner, T., Champaneri, S., & Saudek, C. (2015). Autoantibodies in Type 1 Diabetes. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/2/Autoantibodies_in_Type_1_Diabetes
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2015. [cited 2019 July 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/2/Autoantibodies_in_Type_1_Diabetes.
TY - ELEC
T1 - Autoantibodies in Type 1 Diabetes
ID - 547013
A1 - Donner,Thomas,M.D.
AU - Champaneri,Shivam,M.D.
AU - Saudek,Christopher,M.D.
Y1 - 2015/10/06/
BT - Johns Hopkins Diabetes Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/2/Autoantibodies_in_Type_1_Diabetes
DB - Johns Hopkins Guide
DP - Unbound Medicine