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- Leptospira is one of 4 spirochetes pathogenic for humans (others being Borrelia burgdorferi causing Lyme Disease, relapsing fever Borreliae, and Treponema pallidum [syphilis]).
- Multiple species described and many serovars both pathogenic and non-pathogenic for humans.
- Zoonotic disease, transmitted by domestic animals (dogs, cattle, pigs, and more) and rodents (rats, mice).