Johns Hopkins Antibiotic (ABX) GuidePathogensBacteria

Legionella species (See also: Legionnaires disease)

Legionella species (See also: Legionnaires disease) is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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  • Gram negative aerobe, cause of legionellosis or Legionnaires’ disease.
  • Common environmental organism, found in warm water sources (e.g., 32°- 45°C temperature range as in warm ponds, air chillers or industrial air conditioning systems).
  • At least 50 species and 70 serogroups, most common human pathogen: L. pneumophila.
    • Other human pathogens (in order of frequency): L. micdadei, L. bozemanae, L. dumoffii and L. longbeachae.
  • Side chain carbohydrate groups (O antigen determinants), thought to most contribute to serological classification of this species.
  • An intracellular pathogen, effective drugs in animal models include fluoroquinolones, macrolides, TMP-SMX, rifampin and doxycycline.

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Last updated: August 27, 2012