Hepatitis D is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Hepatitis D virus (HDV) is a defective RNA virus, Hepatitis delta virus. It cannot replicate on its own in the human host.
    • Enveloped, circular RNA.
    • 8 HDV genotypes described with similar transmission and risk groups.
      • HDV genotype 1: mostly seen in North America, Europe, the Middle East, and North Africa.
      • HDV genotype 2: East Asia
      • HDV genotype 3: only in the Amazon Basin
      • HDV genotypes 5, 6, 7, and 8: West and Central Africa.
  • HDV requires active hepatitis B virus (HBV) for replication.
    • Either super-infection or co-infection scenarios with HBV can occur

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MICROBIOLOGY

  • Hepatitis D virus (HDV) is a defective RNA virus, Hepatitis delta virus. It cannot replicate on its own in the human host.
    • Enveloped, circular RNA.
    • 8 HDV genotypes described with similar transmission and risk groups.
      • HDV genotype 1: mostly seen in North America, Europe, the Middle East, and North Africa.
      • HDV genotype 2: East Asia
      • HDV genotype 3: only in the Amazon Basin
      • HDV genotypes 5, 6, 7, and 8: West and Central Africa.
  • HDV requires active hepatitis B virus (HBV) for replication.
    • Either super-infection or co-infection scenarios with HBV can occur

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Last updated: January 13, 2023