Prosthetic Joint Infections
Prosthetic Joint Infections is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Staphylococci account for >50% of total prosthetic joint infections (PJI). Gram negatives may account for 15%. Approximately 20% may be polymicrobial.
- Culture negative infections represent ~7-11% of infections; some may be due to prior abx therapy.
- Bacterial:
- Staphylococcus (coagulase-negative)
- Staphylococcus aureus
- Viridans streptococci
- Propionibacterium acnes (especially shoulder implant infections)
- Enterococcal species
- Gram-negative enteric bacteria
- Pseudomonas aeruginosa
- Anaerobes
- Brucella spp: rare
- Mycobacterial:
- Non-tubercular mycobacteria: rare
- M. tuberculosis: very rare
- Fungal:
- Candida species
- Typical pathogens by time of onset following prosthesis placement:
- Early infection (0-3 months post-op): predominantly S. aureus, β-hemolytic strep, Gram-negative bacilli
- Delayed (3 mos-2 yrs): usual pathogens include coagulase-negative Staphylococci,S. aureus , P. acnes
- Late (>2 yrs): S. aureus, coagulase-negative Staphylococci, viridans Streptococci, Enterococci, P. acnes
- Less common: Gram-negatives
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Last updated: May 30, 2016
Citation
Keller, Sara, and Paul G Auwaerter. "Prosthetic Joint Infections." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540256/all/Prosthetic_Joint_Infections.
Keller S, Auwaerter PG. Prosthetic Joint Infections. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540256/all/Prosthetic_Joint_Infections. Accessed August 18, 2019.
Keller, S., & Auwaerter, P. G. (2016). Prosthetic Joint Infections. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540256/all/Prosthetic_Joint_Infections
Keller S, Auwaerter PG. Prosthetic Joint Infections [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 August 18]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540256/all/Prosthetic_Joint_Infections.
* Article titles in AMA citation format should be in sentence-case
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T1 - Prosthetic Joint Infections
ID - 540256
A1 - Keller,Sara,M.D.
AU - Auwaerter,Paul,M.D.
Y1 - 2016/05/30/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540256/all/Prosthetic_Joint_Infections
PB - The Johns Hopkins University
DB - Johns Hopkins Guide
DP - Unbound Medicine
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