- Febrile neutropenia
- Fever: single oral temp ≥38.3°C (101°F) or temp ≥38°C (100.4°F) sustained for 1h AND
- Neutropenia: absolute neutrophil count (ANC) ≤500 cells/mm3 OR ANC predicted to decrease to ≤500 cells/mm3 in 48h
- Neutrophils create host responses, especially to bacterial and fungal infections. The depth and duration of neutropenia determine the degree of immunocompromise.
- Caveat: Course may be fulminant, and signs and symptoms typical of bacterial infection (i.e., induration, erythema, pustulation, CXR infiltrates, CSF pleocytosis) may be absent.
- The mortality rate is as high as 50% in those presenting to the hospital with severe sepsis or shock.
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Last updated: January 13, 2023
Spacek, Lisa A. "Fever and Neutropenia." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia.
Spacek LA. Fever and Neutropenia. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia. Accessed December 8, 2023.
Spacek, L. A. (2023). Fever and Neutropenia. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia
Spacek LA. Fever and Neutropenia [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2023 December 08]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia.
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