Chlamydia pneumoniae

Valeria Fabre, M.D., John G. Bartlett, M.D.
Chlamydia pneumoniae is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Obligate intracellular Gram-negative bacteria.
    • Grows like a virus (requires cell culture systems) but is a bacterium with RNA and DNA.
    • As intracellular organism-parasite, requires host cell for ATP/GTP.
    • Known to also cause disease in koalas, reptiles and amphibians.
  • Elementary body is metabolically inactive form, has rigid cell wall that permits survival outside cell [Fig]. Inside cell is seen as inclusion body.
  • Incubation culture to positivity: average 21 d.
  • Historically known as the "TWAR" agent, as two of the original isolates were from Taiwan.

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MICROBIOLOGY

  • Obligate intracellular Gram-negative bacteria.
    • Grows like a virus (requires cell culture systems) but is a bacterium with RNA and DNA.
    • As intracellular organism-parasite, requires host cell for ATP/GTP.
    • Known to also cause disease in koalas, reptiles and amphibians.
  • Elementary body is metabolically inactive form, has rigid cell wall that permits survival outside cell [Fig]. Inside cell is seen as inclusion body.
  • Incubation culture to positivity: average 21 d.
  • Historically known as the "TWAR" agent, as two of the original isolates were from Taiwan.

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Last updated: February 3, 2019