Johns Hopkins ABX Guide
Bacterial Cystitis, Acute, Uncomplicated
PATHOGENS
- Uncomplicated UTI: >95% of these infections are due to a single organism.
- Culprit pathogens:
- E. coli (75-95%)
- Uropathogenic E. coli (UPEC) most likely to cause UTIs are groups B2 and D, which have "fitness elements," providing them with an advantage in this extraintestinal niche.
- Other Enterobacteriaceae (e.g., K. pneumoniae, P. mirabilis)
- S. saprophyticus
- Uncommon pathogens: P. aeruginosa, Group D Streptococci
- Rare pathogens: H. influenzae,M. tuberculosis, anaerobes, Salmonella, Shigella, adenovirus type 11, Ureaplasma, Mycoplasma, Enterococcus spp., Group B Streptococci
- Enterococcus spp. and group B Streptococcus alone rarely cause uncomplicated cystitis (see excellent Hooton NEJM 2013 reference[5]).
- These two organisms are recovered from midstream urine specimens of ~10% of women with cystitis but are rarely (1%) also isolated from paired catheter urine specimens.
- Enterococcus spp. and group B Streptococcus alone rarely cause uncomplicated cystitis (see excellent Hooton NEJM 2013 reference[5]).
- E. coli (75-95%)
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Last updated: October 15, 2022
Citation
Melia, Michael. "Bacterial Cystitis, Acute, Uncomplicated." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis_Acute_Uncomplicated.
Melia M. Bacterial Cystitis, Acute, Uncomplicated. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis_Acute_Uncomplicated. Accessed December 2, 2023.
Melia, M. (2022). Bacterial Cystitis, Acute, Uncomplicated. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis_Acute_Uncomplicated
Melia M. Bacterial Cystitis, Acute, Uncomplicated [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2023 December 02]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis_Acute_Uncomplicated.
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