Tricyclic Antidepressants (TCA)

Michelle Yang, Pharm.D., BCPP

INDICATIONS

FDA

NON-FDA APPROVED USES

  • Amitriptyline - Cyclical vomiting syndrome prophylaxis; fibromyalgia; headache treatment/prophylaxis; irritable bowel syndrome; chronic neck pain; neuropathy; postherpetic neuralgia treatment/prophylaxis; tinnitus; temporomandibular joint disorder
  • Imipramine - Binge eating disorder, bulimia nervosa, neuropathy due to diabetes mellitus, panic disorder, posttraumatic stress disorder, urinary incontinence
  • Doxepin - Cyclical vomiting syndrome prophylaxis; urticaria
  • Clomipramine - Autism spectrum disorder; depression; panic disorder; premature ejaculation
  • Nortriptyline - Cyclical vomiting syndrome prophylaxis; neuropathy due to diabetes mellitus; postherpetic neuralgia; smoking cessation assistance
  • Desipramine - Neuropathy due to diabetes mellitus; postherpetic neuralgia

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