Trimethoprim + Sulfamethoxazole

Kathryn Dzintars, Pharm.D., BCPS
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Trimethoprim + Sulfamethoxazole is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

  • Traveler’s diarrhea
  • Shigellosis
  • Acute exacerbation of chronic bronchitis
  • Otitis media (with documented sensitive S. pneumoniae)
  • Pneumocystis jiroveci pneumonia (PCP, treatment and prophylaxis)
  • Urinary tract infections

NON-FDA APPROVED USES

  • Nocardia
  • Toxoplasmosis (treatment and prophylaxis)
  • Bacterial cystitis prophylaxis
  • Isospora infections
  • Salmonella
  • MSSA and MRSA infections
  • Legionella (second line)
  • Listeria treatment (second-line for PCN-allergic patients, including meningitis)

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INDICATIONS

FDA

  • Traveler’s diarrhea
  • Shigellosis
  • Acute exacerbation of chronic bronchitis
  • Otitis media (with documented sensitive S. pneumoniae)
  • Pneumocystis jiroveci pneumonia (PCP, treatment and prophylaxis)
  • Urinary tract infections

NON-FDA APPROVED USES

  • Nocardia
  • Toxoplasmosis (treatment and prophylaxis)
  • Bacterial cystitis prophylaxis
  • Isospora infections
  • Salmonella
  • MSSA and MRSA infections
  • Legionella (second line)
  • Listeria treatment (second-line for PCN-allergic patients, including meningitis)

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