is a topic covered in the Johns Hopkins HIV Guide
To view the entire topic, please sign in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
- Member of aerobic actinomycetes group. Grows slowly on media. Appear as branching, beaded filamentous Gram-positive rods.
- Variably acid fast due to presence of intermediate mycolic acids in cell wall, distinguishes from Actinomyces. May produce sulfur granules, especially in mycetomas.
- Ubiquitous in environment. Most infections acquired by inhalation or direct inoculation.
- Many (possibly all) isolates previously identified as "N. asteroides" now known to have been mis-identified based on current lab standards; type strain of N. asteroides does not appear to have been recovered from recent clinical isolates.
- Human pathogens include N. abscessus (former N. asteroides Type I drug susceptibility pattern), N. brevicatena/paucivorans complex (Type II), N. nova complex (III), N. transvalensis complex (IV), N. farcinica (V; more virulent), and N. cyriacigeorgica (VI), as well as N. brasiliensis (more common in tropics and actinomycetoma) and N. pseudobrasiliensis.
- Each species/complex generally has stereotyped antimicrobial susceptibility patterns.
-- To view the remaining sections of this topic, please sign in or purchase a subscription --