Metronidazole

Paul A. Pham, Pharm.D., John G. Bartlett, M.D.

Metronidazole is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

Anaerobic infections: Intra-abdominal infections; skin and skin structure infections and bone and joint infections
Bacterial septicemia; endocarditis (caused by Bacteroides spp.).
Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection).
Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus).
Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori.
CNS infections (meningitis and brain abscess).
Treatment of acute intestinal amebiasis and amebic liver abscess.
Treatment of symptomatic and asymptomatic trichomoniasis.
Bacterial vaginosis (vaginal gel)
Rosacea (topical gel).

NON-FDA APPROVED USES

Colitis, antibiotic-associated (treatment).
Periodontal disease
Elective colorectal surgery prophylaxis (classified as contaminated or potentially contaminated).
Treatment of giardiasis and dracunculiasis

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INDICATIONS

FDA

Anaerobic infections: Intra-abdominal infections; skin and skin structure infections and bone and joint infections
Bacterial septicemia; endocarditis (caused by Bacteroides spp.).
Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection).
Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus).
Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori.
CNS infections (meningitis and brain abscess).
Treatment of acute intestinal amebiasis and amebic liver abscess.
Treatment of symptomatic and asymptomatic trichomoniasis.
Bacterial vaginosis (vaginal gel)
Rosacea (topical gel).

NON-FDA APPROVED USES

Colitis, antibiotic-associated (treatment).
Periodontal disease
Elective colorectal surgery prophylaxis (classified as contaminated or potentially contaminated).
Treatment of giardiasis and dracunculiasis

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