Leucovorin

Janessa Smith, Pharm.D., BCPS, Paul A. Pham, Pharm.D.

Leucovorin is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

Prophylaxis for drug-induced bone marrow toxicity (e.g methotrexate, pyrimethamine, or trimethoprim)
Antidote to the toxic effects of folic acid antagonists such as methotrexate, pyrimethamine, and trimethoprim.
Megaloblastic anemias associated with sprue, nutritional deficiency, pregnancy, and infancy when oral folic acid therapy cannot be given.

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INDICATIONS

FDA

Prophylaxis for drug-induced bone marrow toxicity (e.g methotrexate, pyrimethamine, or trimethoprim)
Antidote to the toxic effects of folic acid antagonists such as methotrexate, pyrimethamine, and trimethoprim.
Megaloblastic anemias associated with sprue, nutritional deficiency, pregnancy, and infancy when oral folic acid therapy cannot be given.

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