ART is only effective treatment for HAD.
Comment: Excellent review of current knowledge of HAND.
Comment: A non-significant association was seen between lower ART CNS penetration effectiveness score and CNS OIs. Lower CNS penetration effectiveness score was associated with higher mortality, though it is unclear whether or not this is a causative association.
Comment: Though HAD is rare, milder forms of HAND are common even among those on ART.
Comment: Neuropsychological improvement peaked 24-36 wks after starting ART; CNS penetration index associated with improvement.
Comment: Drugs with higher CNS penetration associated with lower CSF viral loads.
Comment: Authors observed statistically significant reduction in rate of viral replication for d4T added 24 hrs prior to infection.
Comment: Association between plasma HIV RNA and CSF levels of HIV and beta-2-microglobulin suggests that both viral load and CNS immune activation are important determinants of neurological disease.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Complete Product Information.