Diabetic Ketoacidosis

Anda Gonciulea, M.D., Rita Rastogi Kalyani, M.D., M.H.S.

Diabetic Ketoacidosis is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

A metabolic acidosis characterized by the triad of hyperglycemia (glucose >250 mg/dL), metabolic acidosis (arterial pH ≤ 7.3, serum bicarbonate ≤ 18 meq/L) and moderate ketonuria or ketonemia.
Most, but not all, patients have type 1 diabetes.
Patients with type 2 diabetes also susceptible during acute illness (especially of African American or Hispanic descent) referred to as "ketosis-prone type 2 diabetes," likely due to greater relative insulinopenia[12].

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DEFINITION

A metabolic acidosis characterized by the triad of hyperglycemia (glucose >250 mg/dL), metabolic acidosis (arterial pH ≤ 7.3, serum bicarbonate ≤ 18 meq/L) and moderate ketonuria or ketonemia.
Most, but not all, patients have type 1 diabetes.
Patients with type 2 diabetes also susceptible during acute illness (especially of African American or Hispanic descent) referred to as "ketosis-prone type 2 diabetes," likely due to greater relative insulinopenia[12].

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