Trovafloxacin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Trovafloxacin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Before pulled from the U.S. market for hepatotoxicity reasons, the use of trovafloxacin was reserved for use only if the patient meets all of the following criteria:
    • Has at least one of the following infections that is judged by the treating physician to be serious and life- or limb-threatening:
      • Nosocomial pneumonia
      • Community acquired pneumonia
      • Complicated intra-abdominal
      • Gynecologic, pelvic and skin infections
    • Receives initial therapy in an in-patient heath care facility (i.e., hospital or long-term nursing care facility).
    • The treating physician believes that, even given the new safety information, the benefit of the product for the patient outweighs the potential risk.
    • Use of trovafloxacin was limited to 14 days or less.

NON-FDA APPROVED USES

  • Appendicitis
  • Cholecystitis
  • Cholangitis
  • Diverticulitis
  • Splenic abscess
  • Peritonitis, spontaneous bacterial & secondary
  • Intra-abdominal abscess
  • Hepatic abscess

-- To view the remaining sections of this topic, please log in or purchase a subscription --

INDICATIONS

FDA

  • Before pulled from the U.S. market for hepatotoxicity reasons, the use of trovafloxacin was reserved for use only if the patient meets all of the following criteria:
    • Has at least one of the following infections that is judged by the treating physician to be serious and life- or limb-threatening:
      • Nosocomial pneumonia
      • Community acquired pneumonia
      • Complicated intra-abdominal
      • Gynecologic, pelvic and skin infections
    • Receives initial therapy in an in-patient heath care facility (i.e., hospital or long-term nursing care facility).
    • The treating physician believes that, even given the new safety information, the benefit of the product for the patient outweighs the potential risk.
    • Use of trovafloxacin was limited to 14 days or less.

NON-FDA APPROVED USES

  • Appendicitis
  • Cholecystitis
  • Cholangitis
  • Diverticulitis
  • Splenic abscess
  • Peritonitis, spontaneous bacterial & secondary
  • Intra-abdominal abscess
  • Hepatic abscess

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