Metronidazole

Metronidazole is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Anaerobic infections: intra-abdominal infections, skin and skin structure infections, bone and joint infections
  • Bacterial septicemia; endocarditis (caused by Bacteroides spp.)
  • Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection)
  • Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus)
  • Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori
  • CNS infections (meningitis and brain abscess)
  • Treatment of acute intestinal amebiasis and amebic liver abscess
  • Treatment of symptomatic and asymptomatic trichomoniasis
  • Bacterial vaginosis (vaginal gel)
  • Acne rosacea (topical gel)

NON-FDA APPROVED USES

  • Colitis, antibiotic-associated including C. difficile
  • Treatment of giardiasis and dracunculiasis
  • Periodontal disease
  • Elective colorectal surgery (classified as contaminated or potentially contaminated)

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