Kanamycin

Paul G. Auwaerter, M.D., Y. Vivian Tsai, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS

INDICATIONS

No longer routinely used for these indications.
- Short-term treatment of infections caused by E. coli, Proteus species (indole-positive and indole-negative), Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens, and Acinetobacter species.
  - Note: other aminoglycosides, including gentamicin, tobramycin, and/or amikacin, are preferred in this setting.
- Hepatic encephalopathy (oral formulation)
- Bowel decontamination (oral formulation)

Historically used for NTM infections. Current ATS/ERS/ESCMID/IDSA guidelines do not recommend kanamycin. When a parenteral aminoglycoside is indicated, amikacin is generally preferred; streptomycin remains an option for selected cases of MAC disease.

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