Gentamicin

Caitlin Soto, PharmD, BCIDP , Kathryn Dzintars, Pharm.D., BCPS

INDICATIONS

FDA

  1. Serious infections caused by susceptible strains of organisms.
    1. With the exception of uncomplicated UTI, aminoglycosides are generally used in combination for serious infections.
  2. Bacterial septicemia, including neonatal sepsis
  3. Skin, bone and soft tissue infections (including burns)
  4. Meningitis (poor penetration)
  5. Urinary tract
  6. Respiratory tract (poor penetration)
  7. Gastrointestinal tract (including peritonitis)
  8. Inflammatory ocular conditions that are steroid-responsive (ophthalmic ointment and suspension)

NON-FDA APPROVED USES

  1. Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third-/fourth-generation cephalosporin)
  2. Intra-abdominal infection (in combination with an agent with Gram-positive and anaerobe coverage)
  3. Enterococcal endocarditis (in combination with ampicillin)
  4. Pelvic inflammatory disease (PID, in combination with clindamycin)
  5. Brucella species

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