Gentamicin

Kathryn Dzintars, Pharm.D., BCPS, Paul A. Pham, Pharm.D.

Gentamicin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

Serious infections caused by susceptible strains of organism.
1. With the exception of uncomplicated UTI, aminoglycosides are generally used in combination for serious infections.
Bacterial septicemia, including neonatal sepsis
Skin, bone and soft tissue infections (including burns)
Meningitis (poor penetration)
Urinary tract
Respiratory tract (poor penetration)
Gastrointestinal tract (including peritonitis)
Inflammatory ocular conditions that are steroid-responsive (opthalmic ointment and suspension)

NON-FDA APPROVED USES

Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
Intra-abdominal infection (in combination with an agent with Gram-positive and anaerobe coverage)
Enterococcal endocarditis (in combination with ampicillin)
Pelvic inflammatory disease (PID, in combination with clindamycin)
Infections caused by P. aeruginosa (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
Brucella Species

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INDICATIONS

FDA

Serious infections caused by susceptible strains of organism.
1. With the exception of uncomplicated UTI, aminoglycosides are generally used in combination for serious infections.
Bacterial septicemia, including neonatal sepsis
Skin, bone and soft tissue infections (including burns)
Meningitis (poor penetration)
Urinary tract
Respiratory tract (poor penetration)
Gastrointestinal tract (including peritonitis)
Inflammatory ocular conditions that are steroid-responsive (opthalmic ointment and suspension)

NON-FDA APPROVED USES

Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
Intra-abdominal infection (in combination with an agent with Gram-positive and anaerobe coverage)
Enterococcal endocarditis (in combination with ampicillin)
Pelvic inflammatory disease (PID, in combination with clindamycin)
Infections caused by P. aeruginosa (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
Brucella Species

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