Clarithromycin

Caitlin Soto, PharmD, BCIDP, Kathryn Dzintars, Pharm.D., BCPS
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID

INDICATIONS

Following indications are rarely preferred among these older FDA indications due to the rise of macrolide resistance:
- Pharyngitis and tonsillitis
- Acute maxillary sinusitis (Biaxin and Biaxin XL)
- Acute bacterial exacerbation of chronic bronchitis (Biaxin and Biaxin XL)
- Community-acquired pneumonia (Biaxin and Biaxin XL)
  - For Legionella, current guidelines favor azithromycin or a respiratory fluoroquinolone; clarithromycin remains an effective alternative.
- Acute otitis media
- Uncomplicated skin and skin structure infections
- Treatment of active duodenal ulcer associated with H. pylori infection (in combination with omeprazole or ranitidine, bismuth citrate)
Treatment of disseminated mycobacterial infections due to Mycobacterium avium
Prophylaxis of Mycobacterium avium
Pediatric indications include: pharyngitis/tonsillitis, community-acquired pneumonia, acute maxillary sinusitis, acute otitis media, uncomplicated skin and skin structure infections, disseminated Mycobacterium avium

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