Chloramphenicol

FDA

Chloramphenicol injectable has been discontinued for use in the U.S.

• Note: for use only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated.
• Acute infections caused by Salmonella typhi
• Serious infections caused by Salmonella species, H. influenzae, especially meningeal infections, Rickettsia, Lymphogranuloma-psittacosis Chlamydia group, various Gram-negative bacteria causing bacteremia and meningitis.
• Part of a cystic fibrosis regimen when other agents are ineffective or contraindicated.
• Ocular infections (ophthalmic drops and ointments)

NON-FDA APPROVED USES

• Lung abscess
• Gas gangrene (in PCN allergic pts)
• Brain abscess
• Paratyphoid fever
• Q fever (Coxiella burnetii)
• Rocky Mountain spotted fever and other endemic (murine or scrub) typhus infections caused by Rickettsia species.
• Ehrlichiosis
• Meningitis in PCN-allergic patients.