Ceftriaxone

Kathryn Dzintars, Pharm.D., BCPS, Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Ceftriaxone is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Lower respiratory tract infections
  • Acute bacterial otitis media
  • Skin and skin-structure infections
  • Urinary tract infections (complicated and uncomplicated)
  • Uncomplicated gonorrhea
  • Pelvic inflammatory disease
  • Septicemia
  • Bone and joint infections
  • Intra-abdominal infections
  • Meningitis and surgical prophylaxis

NON-FDA APPROVED USES

  • Brain abscess (with metronidazole)
  • Appendicitis (with metronidazole)
  • Peritonitis: spontaneous bacterial and secondary
  • Endocarditis
  • Diabetic foot infections (with metronidazole or clindamycin)
  • Lyme disease: late Lyme arthritis and neuroborreliosis
  • Meningococcal meningitis prophylaxis: 125 mg x1 (< 15 yrs); 250 mg x1 (≥15 yrs)
  • Neurosyphilis
  • Disseminated GC

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INDICATIONS

FDA

  • Lower respiratory tract infections
  • Acute bacterial otitis media
  • Skin and skin-structure infections
  • Urinary tract infections (complicated and uncomplicated)
  • Uncomplicated gonorrhea
  • Pelvic inflammatory disease
  • Septicemia
  • Bone and joint infections
  • Intra-abdominal infections
  • Meningitis and surgical prophylaxis

NON-FDA APPROVED USES

  • Brain abscess (with metronidazole)
  • Appendicitis (with metronidazole)
  • Peritonitis: spontaneous bacterial and secondary
  • Endocarditis
  • Diabetic foot infections (with metronidazole or clindamycin)
  • Lyme disease: late Lyme arthritis and neuroborreliosis
  • Meningococcal meningitis prophylaxis: 125 mg x1 (< 15 yrs); 250 mg x1 (≥15 yrs)
  • Neurosyphilis
  • Disseminated GC

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