Cefepime

Kathryn Dzintars, Pharm.D., BCPS, Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Cefepime is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Pneumonia caused by S. pneumoniae
    • Including cases associated with concurrent bacteremia, P. aeruginosa, K. pneumoniaeor Enterobacter species.
  • Febrile neutropenia (empiric therapy)
  • Uncomplicated and complicated urinary tract infections including pyelonephritis (+/- bacteremia) caused by E. coli, K. pneumoniae, or P. mirabilis
  • Uncomplicated skin and skin-structure infections caused by MSSA or S. pyogenes.
  • Complicated intra-abdominal infections (in combination with metronidazole) caused by E. coli, viridans group streptococci, P. aeruginosa, K. pneumoniae, Enterobacter species, or B. fragilis.

NON-FDA APPROVED USES

  • Shunt infections, CNS
  • Appendicitis (with metronidazole)
  • Diverticulitis (with metronidazole)
  • Intra-abdominal abscess (with metronidazole)
  • Osteomyelitis, acute
  • Osteomyelitis, chronic
  • Diabetic foot infection (with metronidazole or clindamycin)
  • Hardware associated septic arthritis
  • Acute exacerbations of chronic bronchitis

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INDICATIONS

FDA

  • Pneumonia caused by S. pneumoniae
    • Including cases associated with concurrent bacteremia, P. aeruginosa, K. pneumoniaeor Enterobacter species.
  • Febrile neutropenia (empiric therapy)
  • Uncomplicated and complicated urinary tract infections including pyelonephritis (+/- bacteremia) caused by E. coli, K. pneumoniae, or P. mirabilis
  • Uncomplicated skin and skin-structure infections caused by MSSA or S. pyogenes.
  • Complicated intra-abdominal infections (in combination with metronidazole) caused by E. coli, viridans group streptococci, P. aeruginosa, K. pneumoniae, Enterobacter species, or B. fragilis.

NON-FDA APPROVED USES

  • Shunt infections, CNS
  • Appendicitis (with metronidazole)
  • Diverticulitis (with metronidazole)
  • Intra-abdominal abscess (with metronidazole)
  • Osteomyelitis, acute
  • Osteomyelitis, chronic
  • Diabetic foot infection (with metronidazole or clindamycin)
  • Hardware associated septic arthritis
  • Acute exacerbations of chronic bronchitis

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