Caspofungin acetate

Caspofungin acetate is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other anti-fungal therapy.
    • Candidemia and the following Candida infections: intra-abdominal abscesses, peritonitis and pleural space infections.
    • Note: not well studied in endocarditis, osteomyelitis, and meningitis (low CNS penetration) due to Candida.
  • Esophageal candidiasis (authors’ opinion: would reserve caspofungin for azole-resistant cases).
  • Empiric treatment of presumed fungal infections in febrile neutropenic patients.

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