Azithromycin

Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Azithromycin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Community-acquired pneumonia of mild severity (20%-30% of S. pneumoniae strains resistant to azithromycin but clinical significance unknown)
  • Pharyngitis/tonsillitis
  • Acute bacterial sinusitis.
  • Acute otitis media (pediatric)
  • Acute bacterial exacerbations of chronic obstructive pulmonary disease
  • Treatment and prophylaxis of disseminated M. avium infection (treatment requires co-administration with ethambutol)
  • Uncomplicated skin and skin structure infections
  • Urethritis and cervicitis (caused by GC and C. trachomatis)
  • Genital ulcer disease
  • Bacterial conjunctivitis

NON-FDA APPROVED USES

  • Toxoplasmosis (with pyrimethamine)
  • Meningococcal meningitis prophylaxis
  • Uncomplicated treatment of falciparum malaria (in combination with artesunate)
  • Pertussis
  • Anti-inflammatory therapy in children with cystic fibrosis

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INDICATIONS

FDA

  • Community-acquired pneumonia of mild severity (20%-30% of S. pneumoniae strains resistant to azithromycin but clinical significance unknown)
  • Pharyngitis/tonsillitis
  • Acute bacterial sinusitis.
  • Acute otitis media (pediatric)
  • Acute bacterial exacerbations of chronic obstructive pulmonary disease
  • Treatment and prophylaxis of disseminated M. avium infection (treatment requires co-administration with ethambutol)
  • Uncomplicated skin and skin structure infections
  • Urethritis and cervicitis (caused by GC and C. trachomatis)
  • Genital ulcer disease
  • Bacterial conjunctivitis

NON-FDA APPROVED USES

  • Toxoplasmosis (with pyrimethamine)
  • Meningococcal meningitis prophylaxis
  • Uncomplicated treatment of falciparum malaria (in combination with artesunate)
  • Pertussis
  • Anti-inflammatory therapy in children with cystic fibrosis

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