Johns Hopkins Psychiatry Guide

Dementia with Lewy Bodies

Tamela McClam, M.D., Gregory Pontone, M.D.
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DEFINITION

  • Dementia with Lewy bodies (DLB) is a primary neurodegenerative disorder affecting cognitive function and movement.
    • Early symptoms include prominent deficits in attention, as well as visuospatial and executive dysfunction.
    • Additional features include parkinsonism, hallucinations, cognitive fluctuations, and REM sleep behavior disorder.
  • One of the synucleinopathies
    • Lewy bodies: abnormal protein aggregates composed of α-synuclein
  • Cognitive impairment due to Lewy bodies is classified under the neurocognitive disorders (NCDs) section of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) [1].

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Last updated: November 21, 2014