Coronary Artery Disease is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please or purchase a subscription.

Johns Hopkins Guides provide diagnosis, management, and treatment guidance for infectious diseases, diabetes, and psychiatric conditions. Explore these free sample topics:

Johns Hopkins Guides

~~ The first section of this topic is shown below ~~

PATHOGENS

  • HIV infection appears to increase coronary atherosclerosis and risk of acute coronary syndromes (ACS): 1.1 to 1.6x increased risk; 6-15% of deaths among HIV+ in U.S. and Europe caused by cardiovascular disease
    • Proposed mechanisms: HIV mediated inflammation, coagulation disorders, lipid disturbances, gut translocation
  • ART agents have been associated with increased ACS risk (LPV/r, IDV, ABC, ddI) and increased cholesterol: greatest increase (>20mg/dL) with LPV/r, /r, NFV, TPV/r
    • Increased insulin resistance: most associated with LPV/r, IDV, d4T
    • Potential direct effect leading to ACS: ABC, ddI, LPV, IDV
  • Traditional risk factors:
    • Hypercholesterolemia and low HDL
    • Hypertension
    • Diabetes
    • Central obesity
    • Genetics (family history of MI < 55 yrs)
    • Advancing age
  • Behavioral factors
    • Smoking
    • Recreational drug use (especially cocaine)
    • Lack of exercise

~~ To view the remaining sections of this topic, please
or purchase a subscription ~~

Last updated: November 29, 2015