Peliosis hepatis is a topic covered in the Johns Hopkins HIV Guide.

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PATHOGENS

  • Definition: blood filled cavities (lakes) in liver that develop through Bartonella-induced neo-angiogenesis. Often accompanied by peliosis in the spleen (and also other reticuloendothelial organs - bone, lymphnodes, etc).
  • Causes: in HIV+ pts usually caused be infection by Bartonella spp or TB. In HIV-negative (and some HIV+) pts, caused by anabolic steroids, Castleman’s disease, Hodgkin’s lymphoma, leukemia, other malignancies including hepatic tumors
  • Bartonella (formerly known as Rochalimea): Small, fastidious, gram-negative aerobic bacilli
    • B. henselae: linked to cat and flea exposure
    • B. quintana: linked to homelessness, low-income, and lice exposure
  • TB: reported from TB endemic regions

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Last updated: August 26, 2013