Neisseria gonorrhoeae is a topic covered in the Johns Hopkins HIV Guide.

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MICROBIOLOGY

  • Non-motile, non-spore-forming, gram-negative diplococcus
  • Infects cuboidal & columnar epithelium leading to a vigorous inflammatory response.
  • Selective growth media (Thayer-Martin & New York City) most common; Cx routinely available in Dx of GC infection in settings that can process specimens appropriately. Swabs from urethral, cervical, rectal, pharyngeal, & ocular sites can be Cx’d.
  • Non-amplified molecular testing, including EIA & DNA hybridization probes, may be used. Cervical & urethral swabs can be tested.
  • Nucleic acid amplification tests (NAATs) are the gold standard and may be performed on urethral swabs, cervical swabs, urine, & self-collected vaginal swabs; CDC recommends their use on rectal and pharyngeal swabs even though they are not FDA cleared for that indication

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Last updated: November 29, 2011