Leucovorin is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

  • Prophylaxis for drug induced bone marrow toxicity (e.g methotrexate, pyrimethamine, or trimethoprim)
  • Antidote to the toxic effects of folic acid antagonists such as methotrexate, pyrimethamine, and trimethoprim.
  • Megaloblastic anemias associated with sprue, nutritional deficiency, pregnancy, and infancy when oral folic acid therapy can not be given.

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Last updated: February 21, 2011